A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20
- PMID: 1639386
- DOI: 10.1016/0888-7543(92)90125-c
A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20
Abstract
A highly polymorphic (dC-dA)n.(dG-dT)n dinucleotide repeat at the PLC1 locus on human chromosome 20 has been identified. Primers flanking the dinucleotide repeat were used for PCR amplification of the repeat region in 37 informative kindreds from the Centre d'Etude du Polymorphisme Humain. Two-point linkage analysis indicates that PLC1 is closely linked to several chromosome 20 markers, including D20S16 (Zmax = 41.25; theta = 0.07), D20S17 (Zmax = 42.81; theta = 0.09), and ADA (Zmax = 57.24; theta = 0.05). Multipoint linkage analysis places the PLC1 locus between D20S18 and D20S17, 11.2 and 6.6 cM, respectively, from these loci (sex-averaged distances). In addition, the PLC1 gene shows linkage to the maturity-onset diabetes of the young (MODY) locus on chromosome 20 with a lod score of 4.57 at theta = 0.089.
Similar articles
-
A genetic map of chromosome 20q12-q13.1: multiple highly polymorphic microsatellite and RFLP markers linked to the maturity-onset diabetes of the young (MODY) locus.Am J Hum Genet. 1993 Jan;52(1):110-23. Am J Hum Genet. 1993. PMID: 8094595 Free PMC article.
-
Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20.Diabetes. 1992 Jan;41(1):88-92. doi: 10.2337/diab.41.1.88. Diabetes. 1992. PMID: 1345781
-
Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.Am J Hum Genet. 1992 Mar;50(3):607-18. Am J Hum Genet. 1992. PMID: 1539597 Free PMC article.
-
The use of linkage analysis and the Centre d'Etude Polymorphisme Humain (CEPH) panel of DNA in the study of the arginine vasopressin, oxytocin and prodynorphin gene loci.Prog Brain Res. 1992;93:309-17. doi: 10.1016/s0079-6123(08)64581-1. Prog Brain Res. 1992. PMID: 1362280 Review. No abstract available.
-
Genetic mapping of facioscapulohumeral muscular dystrophy.Mol Cell Biol Hum Dis Ser. 1993;3:111-38. doi: 10.1007/978-94-011-1528-5_5. Mol Cell Biol Hum Dis Ser. 1993. PMID: 8111536 Review. No abstract available.
Cited by
-
A genetic map of chromosome 20q12-q13.1: multiple highly polymorphic microsatellite and RFLP markers linked to the maturity-onset diabetes of the young (MODY) locus.Am J Hum Genet. 1993 Jan;52(1):110-23. Am J Hum Genet. 1993. PMID: 8094595 Free PMC article.
-
A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3937-41. doi: 10.1073/pnas.93.9.3937. Proc Natl Acad Sci U S A. 1996. PMID: 8632993 Free PMC article.
-
Genetic mapping of the human and mouse phospholipase C genes.Mamm Genome. 1996 Jul;7(7):501-4. doi: 10.1007/s003359900151. Mamm Genome. 1996. PMID: 8672127
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous
