Chromatin, transcript elongation and alternative splicing
- PMID: 16395314
- DOI: 10.1038/nsmb0106-5
Chromatin, transcript elongation and alternative splicing
Abstract
A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.
Comment on
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The human SWI/SNF subunit Brm is a regulator of alternative splicing.Nat Struct Mol Biol. 2006 Jan;13(1):22-9. doi: 10.1038/nsmb1030. Epub 2005 Dec 11. Nat Struct Mol Biol. 2006. PMID: 16341228
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