doi: 10.1016/0027-5107(75)90287-0.
Azaguanine-resistant mutants induced by several mutagens in a neurospora heterokaryon
- PMID: 163959
- DOI: 10.1016/0027-5107(75)90287-0
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Azaguanine-resistant mutants induced by several mutagens in a neurospora heterokaryon
Mutat Res.
1975 Mar.
Abstract
This paper reports the development of a new system for the detection of forward mutations in a heterokaryon of Neurospora crassa. This system, designed to detect a wide variety of genetic alterations, is based upon the detection of 8-azaguanine-resistant mutants in an adenine-requiring heterokaryon carrying the aza-3 gene. Induction of mutations in the aza-3 gene was detected after treatment of conidia with ultraviolet light, X-rays, ethyl methanesulfonate (EMS), or the acridine mustard, ICR-170. The pattern of appearance of mutant colonies and various factors in mutant selection are discussed.
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