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. 2005 Nov-Dec;20(6):374-81.
doi: 10.1177/153331750502000608.

Genetic susceptibility for Alzheimer's disease: why did adult offspring seek testing?

Ann C Hurley  1 , Faan Rose Harvey, J Scott Roberts, Chantel Wilson-Chase, Stephanie Lloyd, Janalyn Prest, Margaret Lock, Kathy J Horvath, Robert C Green
Affiliations

Genetic susceptibility for Alzheimer's disease: why did adult offspring seek testing?

Ann C Hurley et al. Am J Alzheimers Dis Other Demen. 2005 Nov-Dec.

Abstract

This study explored why adult offspring of individuals with Alzheimer's disease (AD) sought genetic susceptibility testing for AD. Participants (N = 60) were a subset of subjects from the first randomized controlled clinical trial to offer such testing. Qualitative analysis revealed two central constructs: altruism and learning. Planning for the future, hoping to prevent AD, and need to know were concepts that explained the value of learning. These results add important contextual information into why people might seek information on their genetic risk for a severe neurodegenerative disease for which there are, as yet, no preventative treatments. As genetic susceptibility testing for numerous other diseases enters clinical medicine, these findings can enhance the knowledge and sensitivity of researchers and clinicians when they are asked by participants or patients whether they should be tested.

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References

    1. Zallen DT: Does It Run in the Family? A Consumer's Guide to DNA Testing for Genetic Disorders. New Brunswick, NJ: Rutgers University Press, 1997.
    1. Nee LE, Tierney MC, Lippa CF: Genetic aspects of Alzheimer's disease, Pick's disease, and other dementias. Am J Alzheimer Dis Other Dement. 2004; 19(4): 219-224. - PMC - PubMed
    1. Pericak-Vance MA, Bass MP, Yamaoka LH, et al.: Complete genomic screen in late-onset familial Alzheimer disease. JAMA. 1997; 278(15): 1237-1241. - PubMed
    1. Roses AD: Genetic testing for Alzheimer disease: Practical and ethical issues. Arch Neurol. 1997; 54: 1226-1229. - PubMed
    1. Farrer LA, Cupples LA, van Duijn CM, et al.: Apolipoprotein E genotype in patients with Alzheimer's disease: Implications for the risk of dementia among relatives. Ann Neurol. 1995; 38(5): 797-808. - PubMed

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