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Review
. 2006 Jan;82(963):24-30.
doi: 10.1136/pgmj.2005.036087.

Growth hormone and its disorders

J Ayuk  1 , M C Sheppard
Affiliations
Review

Growth hormone and its disorders

J Ayuk et al. Postgrad Med J. 2006 Jan.

Abstract

Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting postnatal longitudinal growth as well as protein, lipid, and carbohydrate metabolism. GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults. This article, aimed at non-paediatric physicians, examines the clinical features, diagnosis, and current concepts in the management of these conditions.

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Conflict of interest statement

Conflicts of interest: none.

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