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Case Reports
. 1992 Jul;53(7):242-4.

Clozapine-induced agranulocytosis in a Native American: HLA typing and further support for an immune-mediated mechanism

G M Pfister  1 , D R Hanson, J L Roerig, R Landbloom, M K Popkin
Affiliations
  • PMID: 1639743
Case Reports

Clozapine-induced agranulocytosis in a Native American: HLA typing and further support for an immune-mediated mechanism

G M Pfister et al. J Clin Psychiatry. 1992 Jul.

Abstract

Background: Approximately 30% of schizophrenic patients defined as treatment refractory significantly improve with clozapine. However, clozapine produces agranulocytosis in approximately 1% to 2% of patients in the United States. The mechanism of clozapine-induced agranulocytosis has not been established, but evidence suggests an immune-mediated mechanism.

Method: Human leukocyte antigen (HLA) typing was performed in a native American with clozapine-induced agranulocytosis.

Results: Our findings support previous observations of a role of the HLA-B16, DR4, DQw3 haplotype in predicting susceptibility to agranulocytosis in clozapine-treated patients.

Conclusion: We suggest that HLA typing of clozapine candidates may be useful for predicting the risk for clozapine-induced agranulocytosis.

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Comment in

  • HLA typing costs.
    Landy DA. Landy DA. J Clin Psychiatry. 1993 Jun;54(6):236-7. J Clin Psychiatry. 1993. PMID: 8331095 No abstract available.

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