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Review
. 2006 Jan;10(1):11-20.
doi: 10.1016/j.devcel.2005.12.006.

Mechanisms of mechanotransduction

A Wayne Orr  1 , Brian P Helmke, Brett R Blackman, Martin A Schwartz
Affiliations
Free article
Review

Mechanisms of mechanotransduction

A Wayne Orr et al. Dev Cell. 2006 Jan.
Free article

Erratum in

  • Dev Cell. 2006 Mar;10(3):407

Abstract

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.

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