doi: 10.1073/pnas.72.1.318.
Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA
- PMID: 164018
- PMCID: PMC432296
- DOI: 10.1073/pnas.72.1.318
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Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA
Proc Natl Acad Sci U S A.
1975 Jan.
Abstract
Studies on the nature and location of the methylated nucleotides in mRNA synthesized in vitro by vaccinia virus particles revealed an unusual 5'-terminal structure. Evidence that the pyrophosphate group is blocked by 7-methylguanosine and that both 2'-O-methyl-adenosine and 2'-O-methylguanosine occupy penultimate positions was presented. According to this model, the 5'-termini of vaccinia virus mRNAs are: 7MeG-5'ppp-5'GMepNp and 7MeG-5'AMepNp.
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