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. 1975 Jan;72(1):318-22.
doi: 10.1073/pnas.72.1.318.

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA

C M Wei, B Moss

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA

C M Wei et al. Proc Natl Acad Sci U S A. 1975 Jan.

Abstract

Studies on the nature and location of the methylated nucleotides in mRNA synthesized in vitro by vaccinia virus particles revealed an unusual 5'-terminal structure. Evidence that the pyrophosphate group is blocked by 7-methylguanosine and that both 2'-O-methyl-adenosine and 2'-O-methylguanosine occupy penultimate positions was presented. According to this model, the 5'-termini of vaccinia virus mRNAs are: 7MeG-5'ppp-5'GMepNp and 7MeG-5'AMepNp.

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References

    1. J Mol Biol. 1970 May 28;50(1):1-18 - PubMed
    1. Nucleic Acids Res. 1974 Jun;1(6):809-22 - PubMed
    1. J Mol Biol. 1974 Jun 15;86(1):31-48 - PubMed
    1. Arch Biochem Biophys. 1968 Mar 20;124(1):483-92 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Oct;71(10):3979-83 - PubMed

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