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Comparative Study
. 2006 Jan 10;66(1):102-4.
doi: 10.1212/01.wnl.0000191395.69438.12.

Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration

Jennifer L Whitwell  1 , Clifford R Jack Jr, Matthew L Senjem, Keith A Josephs
Affiliations
Comparative Study

Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration

Jennifer L Whitwell et al. Neurology. .

Abstract

The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.

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Figures

Figure 1
Figure 1
Surface rendering showing patterns of grey matter atrophy (shown in red) in A) FTLD-U compared to controls, B) FTLD-MND compared to controls, and C) FTLD-U compared to FTLD-MND (uncorrected, p<0.001). In addition, the patterns of atrophy in FTLD-U and FTLD-MND compared to controls are displayed on a mid-slice render (D and E respectively); the brain has been split down the mid-sagittal plane using Analyze 6.1 and transparency renders through the left hemisphere (displayed on the right) and right hemisphere (displayed on the left) are shown.
See this image and copyright information in PMC

Comment in

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