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Clinical Trial
. 2006 Jan 10;66(1):105-7.
doi: 10.1212/01.wnl.0000188757.38495.23.

Autologous peripheral blood stem cell transplantation for POEMS syndrome

S Kuwabara  1 , S Misawa, K Kanai, Y Kikkawa, M Nishimura, C Nakaseko, R K Cho, T Hattori
Affiliations
Clinical Trial

Autologous peripheral blood stem cell transplantation for POEMS syndrome

S Kuwabara et al. Neurology. .

Abstract

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.

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