Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jan;48(1):1-12.
doi: 10.1097/01.jom.0000190300.51629.e0.

A retrospective occupational cohort study of end-stage renal disease in aircraft workers exposed to trichloroethylene and other hydrocarbons

Larry Radican  1 , Daniel Wartenberg, George G Rhoads, Dona Schneider, Richard Wedeen, Patricia Stewart, Aaron Blair
Affiliations

A retrospective occupational cohort study of end-stage renal disease in aircraft workers exposed to trichloroethylene and other hydrocarbons

Larry Radican et al. J Occup Environ Med. 2006 Jan.

Abstract

Objective: Case-control studies suggest hydrocarbons increase end-stage renal disease (ESRD) risk. No cohort studies have been conducted.

Methods: An occupational database was matched to the U.S. Renal Data System, and the outcome of all-cause ESRD was examined using multivariable Cox regression. Sixteen individual hydrocarbons were studied, although exposures were not mutually exclusive.

Results: For the 1973-2000 period, there was an approximate twofold increased risk of ESRD among workers exposed to trichloroethylene, 1,1,1-trichloroethane, and JP4 gasoline compared with unexposed subjects (all P < 0.05). Relative risk was greater than unity (P > 0.05) for several other hydrocarbons. Associations attenuated (all P > 0.05) when 2001-2002 data were included in the analyses.

Conclusions: Certain hydrocarbons may increase all-cause ESRD risk. Uncertainty regarding the mechanism for increased risk and the observed attenuation in risk in 2001-2002, as well as the overlap of exposures, complicates interpretation. Additional research is needed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. US Renal Data System. USRDS 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2003. Available at: www.usrds.org
    1. Wedeen RP. Renal diseases of occupational origin. Occup Med. 1992;7:449–463. - PubMed
    1. Nelson NA, Robins TG, Port FK. Solvent nephrotoxicity in humans and experimental animals. Am J Nephrol. 1990;10:10–20. - PubMed
    1. Ravnskov U. Hydrocarbons may worsen renal function in glomerulonephritis: a meta-analysis of the case–control studies. Am J Ind Med. 2000;37:599–606. - PubMed
    1. International Programme on Chemical Safety (IPCS). Environmental Health Criteria 50. Geneva: World Health Organization; 1985. Available at: http://www.inchem.org/documents/ehc/ehc/ehc50.htm

Publication types