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. 2006 Feb 13;94(3):446-9.
doi: 10.1038/sj.bjc.6602921.

Evaluating the role of human papillomaviruses in conjunctival neoplasia

M L Tornesello  1 , M L Duraturo, K M Waddell, B Biryahwaho, R Downing, S Balinandi, S B Lucas, L Buonaguro, F M Buonaguro
Affiliations

Evaluating the role of human papillomaviruses in conjunctival neoplasia

M L Tornesello et al. Br J Cancer. .

Abstract

Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0-1.6%) in control subjects. The absence of high-risk HPVs and the low detection frequency of EV-related HPV types in more advanced tumour stages (10%) raise doubts about their role in conjunctival carcinomas.

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