doi: 10.1007/s11030-006-8696-2.
Three-component reaction between triphenylphosphine, dialkyl acetylenedicarboxylates and urea or N-methylurea
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- PMID: 16404526
- DOI: 10.1007/s11030-006-8696-2
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Three-component reaction between triphenylphosphine, dialkyl acetylenedicarboxylates and urea or N-methylurea
Mol Divers.
2006 Feb.
Abstract
The stabilized phosphoranes, obtained from the three-component reaction between dialkyl acetylenedicarboxylates and urea or N-methylurea in the presence of triphenylphosphine, undergo a smooth reaction in boiling toluene to produce iminophosphoranes in good yields. Under the same reaction conditions, the phosphorane obtained from N-methylurea and dimethyl acetylenedicarboxylate yields methyl 1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylate.
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