[Helicobacter pylori--clinical manifestations, diagnosis and therapy]

Abstract

During the past 20 years the role of Helicobacter pylori have been topic of intensive research. Studies have established that H. pylori can cause acute and chronic gastritis, duodenitis, gastric peptic ulcers and duodenal ulcers non-ulcer dyspepsia and Weird diseases and syndroms. H. pylori has been identified as a risk factor for gastric cancer and MALT-lymphoma. Nearly more than 90% of patients with duodenal ulcus, more than 70% of those with gastric ulcer and more than 80% patients with the gastric cancer have H. pylori infection. The discovery of the infective nature of peptic diseases and involvement of of H. pylori in theirs aetiology has begin to change our views on haw to approach diagnosis and therapeutic treatment in the practice. For this aim have been developed several methods which can be used to diagnose of H. pylori: invasive as endoscopy and non-invasive such as urea-breath-test, detection of antigens in stool, detection of specific antibodies in patients sera by means of serological tests--ELISA and Immunblott, molecular tests PCR and fluorescence-in situ- hybridisation for the detection of H. pylori and its resistance for clarithromycine and metronidazole. There are several effective treatments which can cure gastric and duodenal ulcers as well as prevent theirs recurrences.