[Subclinical and manifested hypothyroidism as a consequence of thyroid autoimmune disease]
- PMID: 16405254
- DOI: 10.2298/sarh05s1034m
[Subclinical and manifested hypothyroidism as a consequence of thyroid autoimmune disease]
Abstract
Chronic thyroiditis (Hashimoto's disease) is a slowly developing persistent inflamation of the thyroid gland, which frequently leads to hypothyroidism. Some of the up-to-date knowledge about hypothyroidism, both subclinical and manifested, caused by autoimmune disease, was presented. Autoimmune thyroid gland disease can occur at any age, but predominantly affects women after periods of high emotional and physical stress or accidents, as well as during periods of hormonal changes. It can also develop in families, and having an autoimmune disease slightly increases the risk of developing another. This paper showed an increasing incidence of subclinical hypothyroidism (4.17%) in elderly, and, at the same time, the incidence of primary hypothyroidism accounting for 1%. It is very usefull to estimate the stimulated thyrotropin (TSH) response, as well as the value of fast, short time thyroid gland reserves, analyzed by T3 and T4 serum level at 60th minute after TRH stimulation. Treatment of choice for HT (hypothyroidism of any cause) is thyroid hormone replacement. Drug of choice is orally administered levothyroxine sodium, usually for life-time. The standard dose is 1.6-1.8 mcg/kg body weight per day, but is in most cases patient dependent. Elderly patients usually require smaller replacement dose of levothyroxine, sometimes less than 1 mcg/kg body weight per day with coronary dilatator at the same time.
Similar articles
-
Incidence of antibodies blocking thyrotropin effect in vitro in patients with euthyroid or hypothyroid autoimmune thyroiditis.J Clin Endocrinol Metab. 1990 Jul;71(1):40-5. doi: 10.1210/jcem-71-1-40. J Clin Endocrinol Metab. 1990. PMID: 2164529
-
[Hypothyreodism. From the latent functional disorder up to coma].Internist (Berl). 2010 May;51(5):568,570-3. doi: 10.1007/s00108-009-2495-7. Internist (Berl). 2010. PMID: 20372870 German.
-
Test for recovery from hypothyroidism during thyroxine therapy in Hashimoto's thyroiditis.Lancet. 1990 Nov 3;336(8723):1084-6. doi: 10.1016/0140-6736(90)92567-2. Lancet. 1990. PMID: 1977978
-
Hypothyroidism in the elderly: pathophysiology, diagnosis and treatment.Drugs Aging. 2005;22(1):23-38. doi: 10.2165/00002512-200522010-00002. Drugs Aging. 2005. PMID: 15663347 Review.
-
[THE CLINICAL APPROACH TO DIAGNOSIS AND TREATMENT OF HYPOTHYROIDISM].Harefuah. 2017 May;156(5):322-325. Harefuah. 2017. PMID: 28551907 Review. Hebrew.
Cited by
-
The Importance of HbA1c Control in Patients with Subclinical Hypothyroidism.Mater Sociomed. 2012;24(4):212-9. doi: 10.5455/msm.2012.24.212-219. Mater Sociomed. 2012. PMID: 23678326 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical