doi: 10.1016/j.ijbiomac.2005.11.008.
Epub 2006 Jan 6.
Fiber molecular model of atelocollagen-small interfering RNA (siRNA) complex
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- PMID: 16405995
- DOI: 10.1016/j.ijbiomac.2005.11.008
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Fiber molecular model of atelocollagen-small interfering RNA (siRNA) complex
Int J Biol Macromol.
.
Abstract
Previously we represented molecular model of collagen triple helix-DNA double helix complex [G.M. Mrevlishvili, D.V. Svintradze, Int. J. Macromol. 36 (2005) 324-326; G.M. Mrevlishvili, D.V. Svintradze, Int. J. Macromol. 35 (2005) 243-245]. We also proved that during the complex formation hydration of triple helix destroys and forms new water bridges maintaining the complex nano-structure. In this paper we demonstrate that small interfering RNA binds to atelocollagen directly to form siRNA-atelocollagen fiber complex.
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