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. 2006 Jun;70(6):1085-8.
doi: 10.1016/j.ijporl.2005.11.006. Epub 2006 Jan 6.

Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung-Man Lee  1 , Sook Ah Park, Seung-Won Chung, Jeong Soo Woo, Sung Won Chae, Sang Hag Lee, Hee Joon Kang, Soon Jae Hwang
Affiliations

Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung-Man Lee et al. Int J Pediatr Otorhinolaryngol. 2006 Jun.

Abstract

Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-gamma-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population.

Study design: Prospective study.

Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.

Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P<0.05).

Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

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