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Comment
. 2006 Jan 17;103(3):507-8.
doi: 10.1073/pnas.0509971102. Epub 2006 Jan 9.

Phytochelatin synthase, papain's cousin, in stereo

Philip A Rea  1
Affiliations
Comment

Phytochelatin synthase, papain's cousin, in stereo

Philip A Rea. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
The catalytic bias of NsPCS favors the deglycylation of GSH to free γ-Glu-Cys (shown in black) over the N-terminal transpeptidation of GSH to generate PC2 [(γ-Glu-Cys)2-Gly] (shown in gray); the converse applies to AtPCS1. The positions of the Cys residues are indicated by white vertical bars, and the conserved His and Asp residues are indicated by blue and red bars, respectively. AtPCS1 residues Cys-56, His-162, and Asp-180 are the three residues that are conserved in all known PC synthases and align with the catalytic residues of NsPCS, Cys-70, His-183, and Asp-201. NsPCS undergoes γ-Glu-Cys acylation at only one site; AtPCS1 undergoes acylation at two sites. The second site of acylation of full-length AtPCS1 is probably in the C-terminal domain (light gray), as is the site for direct interaction with and stimulation by free Cd2+.
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References

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