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Comment
. 2006 Jan 10;103(2):251-2.
doi: 10.1073/pnas.0510051103. Epub 2006 Jan 3.

mGluR7's lucky number

P Jeffrey Conn  1 , Colleen M Niswender
Affiliations
Comment

mGluR7's lucky number

P Jeffrey Conn et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Schematic representation of concentration-response curves for allosteric potentiation (A) versus allosteric agonism (B). In A, a constant amount of allosteric potentiator (red curve) or vehicle (black curve) is added in the presence of increasing amounts of an orthosteric agonist. Although the potentiator has no effect on its own, it shifts the overall concentration-response curve to the left, resulting in an increase in orthosteric agonist potency as depicted by the intersection of the descending lines with the x axis. In B,a constant amount of an allosteric agonist such as AMN082 (red curve) or vehicle (black curve) is added in a similar experimental design; in this case, the entire curve is shifted up with no change in orthosteric agonist potency.
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