[Role of interleukin 10 in inflammatory response after cardiovascular surgery with cardiopulmonary bypass]

Abstract

Cardiac surgery (CS) induces a systemic inflammatory response that may be implicated in postoperative organ dysfunction. The exposure of blood cells and plasma to artificial membranes and the activation of several cell types in the setting of ischemia and reperfusion are believed to play an important role in the development of this reaction. Various mediators have been reported to be involved in the CS-induced reaction, which can lead to postoperative organ dysfunction. Understanding the role of these mediators in systemic inflammatory response may lead to better prognostic assessment and therapeutic modalities. Interleukin 10 (IL-10) is a pleiotropic cytokine produced by both T cells and macrophages and possesses anti-inflammatory properties. IL-10 circulates in the blood of patients undergoing CS with cardiopulmonary bypass (CPB), and increased concentrations of IL-10 have been associated with an adverse clinical outcome. The aim of this work is to review current know-ledge about the role of IL-10 as a regulator of immune response after CS.