Probing cell death by chemical screening
- PMID: 16407999
- DOI: 10.1038/nchembio0705-68
Probing cell death by chemical screening
Abstract
Apoptosis occurs through precise cellular pathways, whereas necrosis is generally thought of as a nonspecific cellular response to external damage. However, identification of a chemical inhibitor of necrotic events suggests that specific molecular pathways can also trigger necrosis.
Comment on
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.Nat Chem Biol. 2005 Jul;1(2):112-9. doi: 10.1038/nchembio711. Epub 2005 May 29. Nat Chem Biol. 2005. PMID: 16408008
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