Chemical biology at the crossroads of molecular structure and mechanism
- PMID: 16408062
- DOI: 10.1038/nchembio1105-300
Chemical biology at the crossroads of molecular structure and mechanism
Abstract
Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.
Similar articles
-
Chemical biology: Directing biosynthesis.Chembiochem. 2007 Jan 2;8(1):141-3. doi: 10.1002/cbic.200600494. Chembiochem. 2007. PMID: 17173271 No abstract available.
-
Highlight: RNA biochemistry.Biol Chem. 2005 Dec;386(12):1203. doi: 10.1515/BC.2005.138. Biol Chem. 2005. PMID: 16336115 No abstract available.
-
[Contribution and limits of biochemical methods].Ann Nutr Aliment. 1974;28(4):233-41. Ann Nutr Aliment. 1974. PMID: 4619303 Review. French. No abstract available.
-
Site-specific labeling of RNA with fluorophores and other structural probes.Methods. 1999 May;18(1):60-70. doi: 10.1006/meth.1999.0757. Methods. 1999. PMID: 10208817
-
On the complementarity of methods in structural biology.Acta Crystallogr D Biol Crystallogr. 2006 Aug;62(Pt 8):941-5. doi: 10.1107/S0907444906008900. Epub 2006 Jul 18. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 16855312 Review.
Cited by
-
Nuclear size, nuclear pore number and cell cycle.Nucleus. 2011 Mar-Apr;2(2):113-8. doi: 10.4161/nucl.2.2.15446. Nucleus. 2011. PMID: 21738834 Free PMC article.
-
Molecular dynamics simulations of RNA: an in silico single molecule approach.Biopolymers. 2007 Feb 5;85(2):169-84. doi: 10.1002/bip.20620. Biopolymers. 2007. PMID: 17080418 Free PMC article. Review.
-
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.Nat Commun. 2015 Apr 22;6:6481. doi: 10.1038/ncomms7481. Nat Commun. 2015. PMID: 25901944 Free PMC article.
-
Epigenetic assays for chemical biology and drug discovery.Clin Epigenetics. 2017 Apr 21;9:41. doi: 10.1186/s13148-017-0342-6. eCollection 2017. Clin Epigenetics. 2017. PMID: 28439316 Free PMC article. Review.
-
Application of metal coordination chemistry to explore and manipulate cell biology.Chem Rev. 2009 Oct;109(10):4921-60. doi: 10.1021/cr900134a. Chem Rev. 2009. PMID: 19715312 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources