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Comparative Study
. 2006 Jan;2(1):29-30.
doi: 10.1038/nchembio753. Epub 2005 Nov 20.

Purmorphamine activates the Hedgehog pathway by targeting Smoothened

Surajit Sinha  1 , James K Chen
Affiliations
Comparative Study

Purmorphamine activates the Hedgehog pathway by targeting Smoothened

Surajit Sinha et al. Nat Chem Biol. 2006 Jan.

Abstract

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

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Comment in

  • Agonizing hedgehog.
    Briscoe J. Briscoe J. Nat Chem Biol. 2006 Jan;2(1):10-1. doi: 10.1038/nchembio0106-10. Nat Chem Biol. 2006. PMID: 16408082 No abstract available.

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