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. 2005 Dec;20(6):557-68.
doi: 10.1080/14756360500212399.

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors

Alexandra Testard  1 , Laurent Picot, Olivier Lozach, Melina Blairvacq, Laurent Meijer, Laurence Murillo, Jean-Marie Piot, Valérie Thiéry, Thierry Besson
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Free article

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors

Alexandra Testard et al. J Enzyme Inhib Med Chem. 2005 Dec.
Free article

Abstract

The microwave-assisted synthesis of a family of 2,8-substituted thiazoloquinazolinones is described. The preliminary evaluation of the antiproliferative activity and the capacity of these molecules to inhibit CDKs and GSK-3 are reported. A lead compound was identified, constituting a scaffold from which more potent inhibitors could be designed.

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