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. 2006 Jan 19;8(2):247-50.
doi: 10.1021/ol052524f.

An efficient synthesis of (+/-)-Lycoricidine featuring a Stille-IMDAF cycloaddition cascade

Hongjun Zhang  1 , Albert Padwa
Affiliations

An efficient synthesis of (+/-)-Lycoricidine featuring a Stille-IMDAF cycloaddition cascade

Hongjun Zhang et al. Org Lett. .

Abstract

[reaction: see text] A highly efficient total synthesis of (+/-)-Lycoricidine is described. The synthesis features the ready preparation of the Lycoricidine skeleton by a Stille-IMDAF cycloaddition cascade. The resulting cycloadduct is then used for the stereocontrolled installation of the other functionality present in the C-ring of the target molecule.

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