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. 2006 Jan 20;71(2):836-9.
doi: 10.1021/jo0520240.

An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine

Richard J B H N van den Berg  1 , Thomas J Boltje, Carlo P Verhagen, Remy E J N Litjens, Gijsbert A van der Marel, Herman S Overkleeft
Affiliations

An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine

Richard J B H N van den Berg et al. J Org Chem. .

Abstract

[reaction: see text] The natural product pachastrissamine, an anhydrophytosphingosine derivative isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized in three steps and with 72% overall yield from d-ribo-phytosphingosine.

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