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. 2006 Aug;20(8):867-72.
doi: 10.1038/sj.eye.6702176. Epub 2006 Jan 13.

The complement system and age-related macular degeneration

S Sivaprasad  1 , N V Chong
Affiliations

The complement system and age-related macular degeneration

S Sivaprasad et al. Eye (Lond). 2006 Aug.

Abstract

Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. There are increasing evidences to suggest the complement system may play a significant role on the pathogenesis of AMD. In this review, we summarise the current research in this area.

Methods: Review of literature.

Results: The complement system is a complex system with several activation pathways. Complement factor H (CFH) polymorphisms has been associated with increase risk of AMD. CFH is an inhibitor protein; the polymorphisms might cause uncontrolled activation by initiation events.

Conclusion: Further studies on the molecular basis of the complement-mediated pathogenesis of AMD may offer novel therapy to AMD.

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