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Review
. 2006 Mar 30;71(7):1006-15.
doi: 10.1016/j.bcp.2005.12.016. Epub 2006 Jan 19.

Empirical antibacterial drug discovery--foundation in natural products

Sheo B Singh  1 , John F Barrett
Affiliations
Review

Empirical antibacterial drug discovery--foundation in natural products

Sheo B Singh et al. Biochem Pharmacol. .

Abstract

Natural products have been a rich source in providing leads for the development of drugs for the treatment of bacterial infections. However, beyond the discovery of the natural product, thienamycin and the synthetic lead, oxazolidinone in the 1970s, there has been a dearth of new compounds. This commentary provides an overview of current antibiotic leads and their mechanism of action, and highlights tools that can be applied to the discovery of new antibiotics.

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