Pathogens reWritE Rho's rules
- PMID: 16413475
- DOI: 10.1016/j.cell.2005.12.024
Pathogens reWritE Rho's rules
Abstract
Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.
Comment on
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Identification of a bacterial type III effector family with G protein mimicry functions.Cell. 2006 Jan 13;124(1):133-45. doi: 10.1016/j.cell.2005.10.031. Cell. 2006. PMID: 16413487
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