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Review
. 2006 Jan 13;124(1):15-7.
doi: 10.1016/j.cell.2005.12.024.

Pathogens reWritE Rho's rules

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Free article
Review

Pathogens reWritE Rho's rules

Richard D Hayward et al. Cell. .
Free article

Abstract

Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.

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