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Review
. 2006 Jan 13;124(1):35-46.
doi: 10.1016/j.cell.2005.12.022.

Protein sensors for membrane sterols

Joseph L Goldstein  1 , Russell A DeBose-Boyd, Michael S Brown
Affiliations
Free article
Review

Protein sensors for membrane sterols

Joseph L Goldstein et al. Cell. .
Free article

Abstract

Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.

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