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Comment
. 2006 Jan;24(1):16-7.
doi: 10.1016/j.immuni.2005.12.007.

IL-1 can act as number one

Ana M Gamero  1 , Joost J Oppenheim
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Free article
Comment

IL-1 can act as number one

Ana M Gamero et al. Immunity. 2006 Jan.
Free article

Abstract

Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.

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