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Review
. 2006 Feb;80(3):1067-76.
doi: 10.1128/JVI.80.3.1067-1076.2006.

Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors

Bryan R Cullen  1
Affiliations
Review

Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors

Bryan R Cullen. J Virol. 2006 Feb.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Schematic representation of the mechanisms of action of APOBEC3G and the HIV-1 Vif protein. See text for detailed discussion. Ub, ubiquitin; 3G, APOBEC3G.
FIG. 2.
FIG. 2.
Potential models to explain the critical role of RNA in mediating the formation of Gag-hA3G complexes. In model II, which suggests that RNA binds to either Gag or hA3G and induces a conformational shift that permits complex formation, the identity of the protein undergoing the conformational shift is left open, i.e., A could be either hA3G or Gag. RNA is shown as a wavy line for simplicity, and RNA binding could be either specific or nonspecific. See text for detailed discussion.
See this image and copyright information in PMC

References

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