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. 2006 Feb 10;6(2):139-44.
doi: 10.1002/mabi.200500202.

Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization

Jukka Holappa  1 , Tapio Nevalainen, Rustam Safin, Pasi Soininen, Tomas Asplund, Tiina Luttikhedde, Már Másson, Tomi Järvinen
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Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization

Jukka Holappa et al. Macromol Biosci. .

Abstract

Novel synthesis methods for the preparation of quaternary piperazine derivatives of chitosan were developed. Quaternary ammonium moiety can be selectively inserted into either one or both of the piperazine nitrogens, yielding structurally uniform chitosan derivative structures. Water-soluble end products were thoroughly characterized with FT-IR, 1H NMR, 13C NMR and 2D 1H-13C HSQC NMR. The molecular weights of the end products were determined by GPC with triple detection.

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