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Comment
. 2006 Jan;126(1):13-4.
doi: 10.1038/sj.jid.5700051.

UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin

John M Wood  1 , Karin U Schallreuter
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UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin

John M Wood et al. J Invest Dermatol. 2006 Jan.
Free article

Abstract

More than 40 years ago Aronoff showed that catalase structure and activity is seriously affected by photo-oxidation of its own substrate, hydrogen peroxide, owing to cleavage of its porphyrin active site. Here we support the results of Maresca et al. and expand on them by using structural modeling of native catalase and its photo-oxidation product, where both methionine and tryptophan residues are oxidized, yielding a deactivated enzyme.

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