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Review
. 2006 Jan;126(1):15-24.
doi: 10.1038/sj.jid.5700004.

Regulatory T cells

Stefan Beissert  1 , Agatha Schwarz, Thomas Schwarz
Affiliations
Free article
Review

Regulatory T cells

Stefan Beissert et al. J Invest Dermatol. 2006 Jan.
Free article

Abstract

Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described. Naturally occurring CD4(+)CD25(+) Tregs are important in the prevention of autoimmune diseases. Type 1 Tregs, another subtype of Treg that is inducible, exert their suppressive activity primarily via the release of IL-10. Detailed knowledge about the phenotype and mode of action of these cells will significantly increase our understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies.

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