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Case Reports
. 2006 Jun;22(6):632-4.
doi: 10.1007/s00381-005-0041-z. Epub 2006 Jan 18.

Chiari I malformation and idiopathic growth hormone deficiency in siblings

R L Murphy  1 , R S Tubbs, P A Grabb, W J Oakes
Affiliations
Case Reports

Chiari I malformation and idiopathic growth hormone deficiency in siblings

R L Murphy et al. Childs Nerv Syst. 2006 Jun.

Abstract

Introduction: The authors report a case of three brothers. Two of these siblings presented with congenital growth hormone deficiency and Chiari I malformation. The third and younger brother has been found not to have growth hormone deficiency or the Chiari I malformation.

Results: Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa has been determined to be altered in patients with Chiari I malformation and growth hormone deficiency.

Conclusion: Our current case reports strengthen the association between these two pathological entities and are, to our knowledge, the first description of both defects in siblings.

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