Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006;20(1):54-6.
doi: 10.1007/s00540-005-0351-z.

Dexmedetomidine during local anesthesia

Mahmoud I M Abdalla  1 , Fatima Al Mansouri, Abdulbari Bener
Affiliations
Randomized Controlled Trial

Dexmedetomidine during local anesthesia

Mahmoud I M Abdalla et al. J Anesth. 2006.

Abstract

The objective of our study was to assess the efficacy and safety of dexmedetomidine given in a small dose for a 1-h infusion as an adjuvant to local analgesia in ophthalmic operations. The study was double-blind prospective, randomized, and placebo controlled. We studied the effects of a small dose of dexmedetomidine (0.5 micro.kg(-1).h(-1) for 10 min followed by 0.2 micro.kg(-1).h(-1) for 50 min. Patients were divided randomly into two groups with 20 patients in each: group A was the study group and group B was the placebo group. Heart rate, systolic blood pressure, and diastolic blood pressure were significantly lower in the dexmedetomidine group than the placebo group. Bispectral index values were significantly lower in the dexmedetomidine group than the placebo group. Also, intraocular pressure significantly decreased in the dexmedetomidine group compared to the placebo group. The study revealed that dexmedetomidine in the studied dose has a sedative effect, provides safe control of heart rate and blood pressure, and also decreases intraocular pressure during ophthalmic surgery under local anesthesia.

PubMed Disclaimer

References

    1. Retina. 1991;11(2):219-20 - PubMed
    1. Anesthesiology. 1997 Feb;86(2):331-45 - PubMed
    1. Anesthesiology. 2000 Aug;93(2):382-94 - PubMed
    1. Crit Care Med. 1995 Sep;23(9):1596-600 - PubMed
    1. Anesthesiology. 1997 Apr;86(4):836-47 - PubMed

Publication types