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Review
. 2006 Jun;50(1):1-7.
doi: 10.1016/j.yhbeh.2005.12.002. Epub 2006 Jan 19.

Sex hormones, central nervous system and pain

Anna Maria Aloisi  1 , Marco Bonifazi
Affiliations
Review

Sex hormones, central nervous system and pain

Anna Maria Aloisi et al. Horm Behav. 2006 Jun.

Abstract

The aim of the present review, which highlights some relationships between sex hormones, the CNS and pain, is to provide reference points for discussion on one of the most intriguing aspects of pain pathophysiology: the presence of sex differences in the response threshold to phasic painful stimuli and in the incidence of chronic pain syndromes. The first part of the review deals with sex steroids and their mechanisms of action. In the second part, the connections between sex steroids, the CNS and pain are illustrated to introduce possible areas of discussion in the study of sex differences in experimental and clinical pain.

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