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. 2006 Feb;90(2):154-7.
doi: 10.1136/bjo.2005.083519.

Non-arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction

G McGwin Jr  1 , M S Vaphiades, T A Hall, C Owsley
Affiliations

Non-arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction

G McGwin Jr et al. Br J Ophthalmol. 2006 Feb.

Retraction in

Abstract

Aim: To determine the association between Viagra (sildenafil) and Cialis (tadalafil) and non-arteritic anterior ischaemic optic neuropathy (NAION).

Methods: A retrospective matched case-control study was conducted. 38 cases of NAION in males were identified from an academic ophthalmology practice in Birmingham, Alabama, and matched (on age) to 38 controls without a history of NAION. Self reported information regarding past and current use of Viagra and/or Cialis was obtained via a telephone questionnaire from interviewers who were not blind to case status.

Results: Overall, males with NAION were no more likely to report a history of Viagra or Cialis use compared to similarly aged controls (odd ratio (OR) 1.75, 95% confidence interval (CI) 0.48 to 6.30 and OR 1.82, 95% CI 0.21 to 15.39). However, for those with a history of myocardial infarction, a statistically significant association was observed (OR 10.7, 95% CI 1.3 to 95.8). A similar association was observed for those with a history of hypertension though it lacked statistical significance (OR 6.9, 95% CI 0.8 to 63.6).

Conclusions: For men with a history of myocardial infarction or hypertension the use of Viagra or Cialis may increase the risk of NAION. Physicians prescribing these medications to patients with these conditions should warn them about the potential risk of NAION.

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References

    1. Hayreh S S.Anterior ischemic optic neuropathy. New York, NY: Springer Verlag, 1975
    1. Hayreh S S. Anterior ischemic optic neuropathy. Arch Neurol 198138675–678. - PubMed
    1. Hayreh S S. Anterior ischemic optic neuropathy: differentiation of arteritic from non‐arteritic type and its management. Eye 1990425–41. - PubMed
    1. Johnson L N, Arnold A C. Incidence of non‐arteritic anterior ischemic optic neuropathy: population based study in the state of Missouri and Los Angeles County, California. J Neuroophthalmol 19941438–44. - PubMed
    1. Ischemic Optic Neuropathy Decompression Trial (IONDT) Research Group Manual of operations. Baltimore: University of Maryland at Baltimore, 199211–2.

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