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Review
. 2006 Feb;91(2):183-7.
doi: 10.1136/adc.2005.073759.

The regulation of appetite

M Druce  1 , S R Bloom
Affiliations
Review

The regulation of appetite

M Druce et al. Arch Dis Child. 2006 Feb.

Abstract

The worsening global obesity epidemic, particularly the increase in childhood obesity, has prompted research into the mechanisms of appetite regulation. Complex pathways modulate energy balance, involving appetite centres in the hypothalamus and brain stem, and hormonal signals of energy status released by the gut and by the periphery. Better understanding of appetite regulation improves understanding of the aetiology of obesity. Manipulation of this homoeostatic system offers potentially useful treatments for obesity.

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Conflict of interest statement

Competing interests: SRB is a Director of Thiakis, a company developing gut hormones as therapeutic agents, and also has shares in the company

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