Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Feb;74(2):1373-5.
doi: 10.1128/IAI.74.2.1373-1375.2006.

Reservoir competency of goats for the Ap-variant 1 strain of Anaplasma phagocytophilum

Affiliations

Reservoir competency of goats for the Ap-variant 1 strain of Anaplasma phagocytophilum

Robert F Massung et al. Infect Immun. 2006 Feb.

Abstract

Field-collected ticks were used to infect goats with either Ap-ha, a strain associated with human disease, or a variant strain, Ap-Variant 1, of Anaplasma phagocytophilum. Goats were shown to be competent as a reservoir for Ap-Variant 1, and challenge and immunosuppression studies were used to further examine infection in the goat model.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Blood smear of EDTA-treated goat blood infected with Ap-Variant 1. The cells in panel A are stained to allow visualization of cellular morphology. Panel B shows the same cells labeled with fluorescein, using anti-A. phagocytophilum antibodies, to identify Ap-Variant 1 bacteria.

References

    1. Courtney, J. W., R. L. Dryden, J. Montgomery, B. S. Schneider, G. Smith, and R. F. Massung. 2003. Molecular characterization of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes scapularis ticks from Pennsylvania. J. Clin. Microbiol. 41:1569-1573. - PMC - PubMed
    1. Gokce, H. I., and Z. Woldehiwet. 1999. Differential haematological effects of tick-borne fever in sheep and goats. Zentbl. Veterinarmed. B 46:105-115. - PubMed
    1. Koptopoulos, G., M. Papanastasopoulou, S. Lekkas, G. Skaragas, and O. Papadopoulos. 1992. Immunosuppression in goats by dexamethasone and cyclophosphamide. Comp. Immunol. Microbiol. Infect. Dis. 15:235-242. - PubMed
    1. Kunicka, J. E., M. A. Talle, G. H. Denhardt, M. Brown, L. A. Prince, and G. Goldstein. 1993. Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of dexamethasone. Cell Immunol. 149:39-49. - PubMed
    1. Levin, M. L., D. J. Coble, and D. E. Ross. 2004. Reinfection with Anaplasma phagocytophilum in BALB/c mice and cross-protection between two sympatric isolates. Infect. Immun. 72:4723-4730. - PMC - PubMed

LinkOut - more resources