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. 2006 Mar;7(3):293-301.
doi: 10.1038/ni1301. Epub 2006 Jan 22.

Identification of a B-1 B cell-specified progenitor

Encarnacion Montecino-Rodriguez  1 , Hyosuk Leathers, Kenneth Dorshkind
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Identification of a B-1 B cell-specified progenitor

Encarnacion Montecino-Rodriguez et al. Nat Immunol. 2006 Mar.

Abstract

The B-1 subpopulation of B lymphocytes differs phenotypically and functionally from conventional B-2 B cells. B-1 B cells are proposed to derive from a distinct progenitor, but such a population has not been isolated. Here we identify and characterize a B-1 B cell progenitor whose numbers peaked in fetal bone marrow but were less abundant in postnatal bone marrow. These Lin(-)CD45R(lo-neg)CD19(+) cells responded to thymic stromal lymphopoietin and 'preferentially' reconstituted functional sIgM(hi)CD11b(+)CD5(lo-neg) B-1 B cells, but not sIgM(+)CD11b(-) B-2 B cells, in vivo. These data indicate that the CD45R(lo-neg)CD19(+) population includes B-1 B cell-specified progenitors and support models proposing distinct developmental pathways for B-1 B cells.

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Comment in

  • B cell lineages: documented at last!
    Herzenberg LA, Tung JW. Herzenberg LA, et al. Nat Immunol. 2006 Mar;7(3):225-6. doi: 10.1038/ni0306-225. Nat Immunol. 2006. PMID: 16482166 No abstract available.

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