Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Feb;38(2):214-7.
doi: 10.1038/ng1712. Epub 2006 Jan 22.

Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia

Penelope E Bonnen  1 , Itsik Pe'er, Robert M Plenge, Jackie Salit, Jennifer K Lowe, Michael H Shapero, Richard P Lifton, Jan L Breslow, Mark J Daly, David E Reich, Keith W Jones, Markus Stoffel, David Altshuler, Jeffrey M Friedman
Affiliations

Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia

Penelope E Bonnen et al. Nat Genet. 2006 Feb.

Abstract

Whole-genome association studies are predicted to be especially powerful in isolated populations owing to increased linkage disequilibrium (LD) and decreased allelic diversity, but this possibility has not been empirically tested. We compared genome-wide data on 113,240 SNPs typed on 30 trios from the Pacific island of Kosrae to the same markers typed in the 270 samples from the International HapMap Project. The extent of LD is longer and haplotype diversity is lower in Kosrae than in the HapMap populations. More than 98% of Kosraen haplotypes are present in HapMap populations, indicating that HapMap will be useful for genetic studies on Kosrae. The long-range LD around common alleles and limited diversity result in improved efficiency in genetic studies in this population and augments the power to detect association of 'hidden SNPs'.

PubMed Disclaimer

Publication types