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Review
. 2005;32(4):479-88.

Stem cell treatment of the heart: a review of its current status on the brink of clinical experimentation

Paolo Angelini  1 , Roger R Markwald
Affiliations
Review

Stem cell treatment of the heart: a review of its current status on the brink of clinical experimentation

Paolo Angelini et al. Tex Heart Inst J. 2005.

Abstract

Stem cells are multipotent, undifferentiated cells capable of multiplication and differentiation. Preliminary experimental evidence suggests that stem cells derived from embryonic or adult tissues (especially bone marrow) may develop into myocardial cells. Some experts believe that this phenomenon occurs naturally in human beings, specifically during recovery from a myocardial infarction. Recently, stem cells have been used with the therapeutic intention of regenerating damaged tissues. Cardiac experiments, mainly with adult homologous stem cells, have proved that this therapy is safe and may improve myocardial vascularization and pump function. We review current fundamental concepts regarding the normal development of embryonic stem cells into myocardial tissue and the heart as a whole. We describe the multiple conditions that naturally enable a stem cell to become a myocardial cell and a group of stem cells to become a heart. We also discuss the challenge of translating basic cellular and molecular mechanisms into effective, clinically relevant treatment options.

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References

    1. Dzau VJ. Simon Dack lecture. American College of Cardiology Scientific Session News; 2004.
    1. Gregoratos G, Abrams J, Epstein AE, Freedman RA, Hayes DL, Hlatky MA, et al. ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE Committee to Update the 1998 Pacemaker Guidelines). J Cardiovasc Electrophysiol 2002;13:1183–99. - PubMed
    1. Rahimtoola SH. The year in valvular heart disease. J Am Coll Cardiol 2004;43:491–504. - PubMed
    1. Favaloro RG. Landmarks in the development of coronary artery bypass surgery. Circulation 1998;98:466–78. - PubMed
    1. Babapulle MN, Joseph L, Belisle P, Brophy JM, Eisenberg MJ. A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents. Lancet 2004;364:583–91. - PubMed