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. 2006 Jan 23:6:17.
doi: 10.1186/1471-2407-6-17.

Prognosis of screen-detected breast cancers: results of a population based study

Laura Cortesi  1 , Vincenzo E Chiuri, Silvia Ruscelli, Valeria Bellelli, Rossella Negri, Ivan Rashid, Claudia Cirilli, Antonella Fracca, Ennio Gallo, Massimo Federico
Affiliations

Prognosis of screen-detected breast cancers: results of a population based study

Laura Cortesi et al. BMC Cancer. .

Abstract

Background: The reduced mortality rate from breast carcinoma among women offered screening mammography is demonstrated after 15-20 years of follow-up. However, the assessment of 5-year overall and event-free survival could represent an earlier measure of the efficacy of mammography screening program (MSP).

Methods: All cases of breast cancer diagnosed in the Province of Modena between years 1996 and 2000 in women aged 50 to 69 years, were identified through the Modena Cancer Registry (MCR). Stage of disease and treatment information were obtained from clinical records. All the events occurring up to June 30, 2003 were retrieved by experienced monitors. Five-year overall and event-free survival were the principal end-points of the study.

Results: During a 5-year period, 587 primary breast cancers were detected by the MSP and 471 primary breast cancers were diagnosed out of the MSP. The screen-detected breast cancers were smaller, more likely node negative, with low histological grade, low proliferative activity and positive receptors status. Furthermore, the breast cancer diagnosed through the MSP more frequently received a conservative surgery. The 5-year survival rate was 94% in the screen-detected group, versus 84% in the other group (p = 0.0001). The rate of 5-year event-free survival was 89% and 75% for the MSP participants and not participants, respectively (p = 0.0001).

Conclusions: Our data confirm a favourable outcome of screen-detected breast cancers in terms of five-year overall and event-free survival, which reflect the good quality assurance parameters of the MSP. Finally, a cancer registry should be implemented in every area covered by screening programs.

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Figures

Figure 1
Figure 1
5-year event-free survival. 5-year event-free survival values between MSP participants and non-participants were equal to 89% and 75% respectively (Log Rank = 19.99). [formula image = MSP participants; formula image = MSP non-participants]
Figure 2
Figure 2
5-yearOS. 5-year OS between MSP participants and non-participants was equal to 94% and 84% respectively (Log Rank = 14.99). [formula image = MSP participants formula image = MSP non-participants]
Figure 3
Figure 3
5-year survival of pT1a+b (3a) and pT1c (3b). 5-year OS values of pT1a+b (a) and pT1c (b) breast cancers between MSP participants and non-participants were equal to 98% and 96% (Log Rank = 0.76) respectively (a) and 93% and 89% (Log Rank = 1.57) respectively (b). [formula image = MSP participants; formula image = MSP non-participants]
Figure 4
Figure 4
5-year survival in N- BC. 5-year OS values of N- breast cancers between MSP participants and non-participants were equal to 95% and 91% respectively (Log Rank = 5.74). [formula image = MSP participants; formula image = MSP non-participants]
Figure 5
Figure 5
5-year survival in N+ BC. 5-year OS values of N+ breast cancers between MSP participants and non-participants were equal to 87% and 73% respectively (Log Rank = 5.02). [formula image = MSP participants; formula image = MSP non-participants]
See this image and copyright information in PMC

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