Review
doi: 10.1016/j.autrev.2005.10.002.
Epub 2005 Nov 2.
Inflammatory and autoimmune complications of common variable immune deficiency
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- PMID: 16431351
- DOI: 10.1016/j.autrev.2005.10.002
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Review
Inflammatory and autoimmune complications of common variable immune deficiency
Autoimmun Rev.
2006 Feb.
Abstract
Common variable immune deficiency (CVID) is associated with autoimmune and inflammatory complications in addition to recurrent infections. The most common conditions are idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, sarcoid-like granulomatous disease and gastrointestinal inflammation. IVIG administration reduces the frequency of infections, but does not always prevent autoimmunity or inflammation. TNF antagonists and anti-CD20 immunomodulators have shown some efficacy in CVID in a few patients; further controlled studies are needed to determine the best management of these conditions in the setting of immunodeficiency.
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