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. 1992 Jul;65(1):50-2.
doi: 10.1007/BF01715127.

TNF induces cytoplasmic vesicles in actinomycin D-treated K 562 cells

R Munker  1 , L Greither, M Darsow, S Pander, W Wilmanns
Affiliations

TNF induces cytoplasmic vesicles in actinomycin D-treated K 562 cells

R Munker et al. Ann Hematol. 1992 Jul.

Abstract

We report here that tumor necrosis factor alpha (TNF) induces peculiar cytoplasmic vesicles in the human erythromyeloid leukemia cell line K 562, sensitized to the cytotoxic action of TNF by a treatment with the inhibitor of transcription actinomycin D. These vesicles are well delineated ultrastructurally. The formation of these vesicles is characteristic for the combination of actinomycin D with TNF and precedes the changes of apoptosis and cellular disintegration. These vesicles correspond to an intermediate step in the cytotoxicity caused by TNF and may indicate that reactive metabolites are involved in the mechanism of action of TNF.

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