Review
doi: 10.1210/er.2005-0006.
Epub 2006 Jan 24.
Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition
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- PMID: 16434512
- DOI: 10.1210/er.2005-0006
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Review
Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition
Endocr Rev.
2006 Apr.
Abstract
Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacting mechanisms that subserve physiological adaptations and pathological disruption of reproduction and growth. Significant advances in systems biology will be needed to address these challenges.
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