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Review
. 2006 Apr;27(2):101-40.
doi: 10.1210/er.2005-0006. Epub 2006 Jan 24.

Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition

Johannes D Veldhuis  1 , James N Roemmich, Erick J Richmond, Cyril Y Bowers
Affiliations
Review

Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition

Johannes D Veldhuis et al. Endocr Rev. 2006 Apr.

Abstract

Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacting mechanisms that subserve physiological adaptations and pathological disruption of reproduction and growth. Significant advances in systems biology will be needed to address these challenges.

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