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. 2006 Jan 24;66(2):265-7.
doi: 10.1212/01.wnl.0000194316.91908.8a.

Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS

F Kimura  1 , C Fujimura, S Ishida, H Nakajima, D Furutama, H Uehara, K Shinoda, M Sugino, T Hanafusa
Affiliations

Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS

F Kimura et al. Neurology. .

Abstract

The authors calculated the progression rate (DeltaFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the DeltaFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the DeltaFS provides an additional predictive index beyond ALSFRS-R alone.

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