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. 2006 Feb 2;8(3):531-4.
doi: 10.1021/ol052907d.

Total synthesis of apratoxin A

Takayuki Doi  1 , Yoshitaka Numajiri, Asami Munakata, Takashi Takahashi
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Total synthesis of apratoxin A

Takayuki Doi et al. Org Lett. .

Abstract

[reaction: see text]. We have achieved a total synthesis of apratoxin A in which thiazoline formation was accomplished from the moCys containing amide 4 using PPh3(O)/Tf2O. Deprotection of the Troc and allyl ester in 17, coupling with tripeptide 3, and deprotection of the allyl ester and the Fmoc, followed by macrolactamization provided apratoxin A (1).

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